Association analyses of the neuregulin 1 gene with schizophrenia and manic psychosis in a Hispanic population
Kaydedildi:
| Yazarlar: | , , , , , , , , , , , , |
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| Materyal Türü: | artículo original |
| Yayın Tarihi: | 2005 |
| Diğer Bilgiler: | Objective: This study used the population of the Central Valley of Costa Rica (CVCR) and phenotyping strategies alternative to DSMIV classifications to investigate the association of neuregulin 1 with schizophrenia. Method: Using 134 family trios with a history of psychosis, we genotyped six of the seven markers originally identified to be associated with schizophrenia in Iceland. Results: The neuregulin Icelandic haplotype was not associated with schizophrenia in the CVCR population. However, a novel haplotype was found to be overrepresented in subjects with functional psychosis (global P-value > 0.05). Stratification of the sample by history of mania suggests that this haplotype may be preferentially over-transmitted to persons with a history of manic psychosis. Conclusion: These results suggest that the neuregulin 1 gene is unlikely to play a major role in predisposing to schizophrenia in the CVCR. Further studies in the CVCR and other Latin American populations should be performed in order to corroborate these findings. |
| Ülke: | Kérwá |
| Kurum: | Universidad de Costa Rica |
| Repositorio: | Kérwá |
| Dil: | Inglés |
| OAI Identifier: | oai:kerwa.ucr.ac.cr:10669/100248 |
| Online Erişim: | https://hdl.handle.net/10669/100248 https://doi.org/10.1111/j.1600-0447.2005.00631.x |
| Anahtar Kelime: | NRG1 schizophrenia manic psychosis |