From dirt to industrial applications: Pseudomonas putida as a Synthetic Biology chassis for hosting harsh biochemical reactions

 

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Detalles Bibliográficos
Autores: Nikel Mayer, Pablo Iván, Chavarría Vargas, Max, Danchin, Antoine, de Lorenzo, Víctor
Formato: artículo original
Fecha de Publicación:2016
Descripción:The soil bacterium Pseudomonas putida is endowed with a central carbon metabolic network capable of fulfilling high demands of reducing power. This situation arises from a unique metabolic architecture that encompasses the partial recycling of triose phosphates to hexose phosphates — the so-called EDEMP cycle. In this article, the value of P. putida as a bacterial chassis of choice for contemporary, industrially-oriented metabolic engineering is addressed. The biochemical properties that make this bacterium adequate for hosting biotransformations involving redox reactions as well as toxic compounds and intermediates are discussed. Finally, novel developments and open questions in the continuous quest for an optimal microbial cell factory are presented at the light of current and future needs in the area of biocatalysis.
País:Kérwá
Institución:Universidad de Costa Rica
Repositorio:Kérwá
OAI Identifier:oai:kerwa.ucr.ac.cr:10669/74419
Acceso en línea:https://www.sciencedirect.com/science/article/pii/S1367593116300515?via%3Dihub
https://hdl.handle.net/10669/74419
Palabra clave:Industrial applications
Pseudomonas putida
Biochemical reactions