Differential effect of environment enrichment and social isolation on depressive-like behavior, spontaneous activity and serotonin and norepinephrine concentration in prefrontal cortex and ventral striatum
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| Autores: | , , |
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| Formato: | artículo original |
| Fecha de Publicación: | 2008 |
| Descripción: | Dawley rats were reared from weaning in either social isolation, standard laboratory conditions, or environmental enrichment. Open-field activity was assessed at postnatal days 37, 65, 93 and 107 and 1 h before the last open-field test, a forced-swimming test was carried out. After behavioral tests, the monoamines concentrations were analyzed in prefrontal cortex and ventral striatum. Relative to control and isolation rearing, the environmental enrichment reduced open-field activity, led to antidepressive-like effects and increased serotonin concentrations in the prefrontal cortex. Social isolation, on the other hand, did not affect open-field activity, but increased depressive-like behavior and reduced the amount of norepinephrine in the ventral striatum. Those neurochemical changes induced by rearing conditions correlated with the behavioral performance in the forced-swimming test. Also, immobility behavior could be predicted by locomotor activity even from the first week of housing. Overall, specific variations in physical and social environment during early rearing lead to some behavioral and neurochemical alterations which might be relevant for understanding the role that neurodevelopmental and experiential factors could have in human depression. |
| País: | Kérwá |
| Institución: | Universidad de Costa Rica |
| Repositorio: | Kérwá |
| OAI Identifier: | oai:kerwa.ucr.ac.cr:10669/73685 |
| Acceso en línea: | https://www.sciencedirect.com/science/article/pii/S0091305707003462 https://hdl.handle.net/10669/73685 |
| Palabra clave: | Depression Environmental enrichment Social isolation Monoamines Prefrontal cortex Striatum Open-field behavior Forced-swimming behavior Stress Brain development Model Rats |