Acute Hepatic Response to Diet Modification and Exercise-induced Endotoxemia during a Laboratory-based Duathlon
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| Autores: | , , , , , , , |
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| Formato: | artículo original |
| Fecha de Publicación: | 2010 |
| Descripción: | The purpose of the study was to compare the acute hepatic response to diet modification and exercise-induced endotoxemia, and to determine if associations exist between liver damage markers, body core temperature, and IL-6 responses to a laboratory-based duathlon. Eleven moderately-trained healthy males followed a low-carbohydrate (CHO) and a high CHO diet to change their glycogen stores two-days before completing a duathlon. Blood samples were obtained at rest, immediately after and 1- and 2-h following the duathlon for determination of endotoxin-lipopolysaccharide binding protein (LPS-LBP) complex, IL-6, and liver integrity markers AST, ALT, and AST/ALT ratio. Hydration status and body core temperature were assessed at rest, during, and after the duathlon. Athletes were more dehydrated and had higher AST/ALT ratios in the lowcompared to the high-CHO diet trial regardless of the measurement time (p<0.05). IL-6 increased from resting to immediately after, 1- and 2-h following duathlon regardless of the diet (p<0.05). A higher LPS-LBP complex concentration was observed from rest to immediately after the duathlon. No significant correlations were found between LPS-LBP complex levels and body core temperature. In conclusion, athletes on a low-CHO diet showed higher hepatic structural damage and finished more dehydrated compared to athletes on a high-CHO diet. Body core temperature and LPS-LBP complex levels were unrelated beyond the increase in body core temperature explained by exercise. No significant associations were found between body core temperature, IL-6 and LPS-LBP complex concentrations. |
| País: | Kérwá |
| Institución: | Universidad de Costa Rica |
| Repositorio: | Kérwá |
| OAI Identifier: | oai:kerwa.ucr.ac.cr:10669/74945 |
| Acceso en línea: | https://www.ingentaconnect.com/content/doaj/0860021x/2010/00000027/00000002/art00007 https://hdl.handle.net/10669/74945 |
| Palabra clave: | human cytokines lipopolysaccharide infammation exercise humano citocinas lipopolisacárido ejercicio inflamación 796.607 8 Ciclismo y actividades relacionadas |