Tissue pathology induced by snake venoms: How to understand a complex pattern of alterations from a systems biology perspective?

 

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Detalles Bibliográficos
Autores: Gutiérrez, José María, Rucavado Romero, Alexandra, Escalante Muñoz, Teresa, Lomonte, Bruno, Angulo Ugalde, Yamileth, Fox, Jay W.
Formato: artículo original
Fecha de Publicación:2010
Descripción:The study of snake venom-induced local tissue pathology has been predominantly based on experimental designs and concepts that view tissue alterations from a dichotomous, homogeneous and reductionist perspective. Experimental observations, however, indicate that cells and extracellular matrix are affected by venoms and toxins in a complex and heterogeneous fashion, and that the effect of whole venoms in whole organisms cannot be properly assessed by studying only the action of isolated toxins in isolated systems. It is proposed that a novel conceptual and methodological frame is necessary to better understand the complexity of these pathological alterations from a holistic, systems biology perspective.
País:Kérwá
Institución:Universidad de Costa Rica
Repositorio:Kérwá
OAI Identifier:oai:kerwa.ucr.ac.cr:10669/29332
Acceso en línea:http://www.sciencedirect.com/science/article/pii/S0041010109004267
https://hdl.handle.net/10669/29332
Palabra clave:Pathology
Snake venom
Systems biology