Drivers of memory loss underreport in mild cognitive impairment due to Alzheimer versus vascular disease
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| Autores: | , , , , , |
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| Formato: | artículo original |
| Fecha de Publicación: | 2024 |
| Descripción: | Background: We examined drivers of self and study partner reports of memory loss in mild cognitive impairment (MCI) from Alzheimer (AD-MCI) and vascular disease (Va-MCI). Methods: We performed retrospective cross-sectional analyses of participants with AD-MCI (n= 2874) and Va-MCI (n=376) from the National Alzheimer Coordinating Center data set. Statistical analysis utilized 2-sided t test or the Fisher exact test. Results: Compared with AD-MCI, Va-MCI subjects (24.5% vs. 19.7%, P=0.031) and study partners (31.4% vs. 21.6%, P<0.0001) were more likely to deny memory loss. Black/African Americans were disproportionately represented in the group denying memory loss in AD-MCI (20.0% vs. 13.2%, P<0.0001) and Va-MCI (33.7% vs. 18.0%, P=0.0022). Study partners of participants with these features also disproportionately denied memory loss: female (AD-MCI: 60.1% vs. 51.7%, P=0.0002; Va-MCI: 70.3% vs. 52.3%, P=0.0011), Black/African American (AD-MCI: 23.5% vs. 11.98%, P<0.0001; Va-MCI: 48.8% vs. 26.5%, P=0.0002), and < 16 years of education (AD-MCI only: 33.9% vs. 16.3%, P=0.0262). In ADMCI and Va-MCI, participants with anxiety were disproportionately represented in the group endorsing memory loss (AD: 28.2% vs. 17.4%, P<0.0001; Va: 31.5% vs. 16.1%, P=0.0071), with analogous results with depression. Conclusion: The findings would suggest extra vigilance in interviewbased MCI detection of persons at-risk for self-based or informantbased misreport. |
| País: | Kérwá |
| Institución: | Universidad de Costa Rica |
| Repositorio: | Kérwá |
| Lenguaje: | Inglés |
| OAI Identifier: | oai:kerwa.ucr.ac.cr:10669/99818 |
| Acceso en línea: | https://hdl.handle.net/10669/99818 https://doi.org/10.1097/wad.0000000000000627 |
| Palabra clave: | Alzheimer disease mild cognitive impairment memory loss self-report study partner reports vascular disease |