Isolation of Major Components from the Roots of Godmania aesculifolia and Determination of Their Antifungal Activities
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| Autores: | , , , , , , |
|---|---|
| Formato: | artículo original |
| Fecha de Publicación: | 2013 |
| Descripción: | From the methanol root extract of Godmania aesculifolia, a species selected in a multinational OAS program aimed at discovering antifungal compounds from Latin American plants, a new chavicol diglycoside (1), the known 3,4-dihydroxy-2-(3-methylbut-2-en-1-yl)-3,4-dihydronaphthalen-1(2H)-one (2), and lapachol (3) were isolated and characterized by 1D and 2D NMR and MS techniques. Only 3 exhibited fairly good activity against a panel of clinical isolates of Cryptococcus neoformans (MIC50 between 7.8 and 31.2 µg/mL) and moderate activities against Candida spp. and non-albicans Candida spp. |
| País: | Kérwá |
| Institución: | Universidad de Costa Rica |
| Repositorio: | Kérwá |
| Lenguaje: | Inglés |
| OAI Identifier: | oai:kerwa.ucr.ac.cr:10669/87976 |
| Acceso en línea: | https://www.thieme-connect.de/products/ejournals/abstract/10.1055/s-0033-1351025 https://hdl.handle.net/10669/87976 |
| Palabra clave: | Godmania aesculifolia Bignoniaceae lapachol Chavicol diglycoside Trichophyton spp. Microsporum spp. Aspergillus spp. Candida Cryptococcus neoformans |