Identification of etoricoxib polymorphic crystalline form in pharmaceutical raw materials
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| Autores: | , , , |
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| Formato: | artículo original |
| Fecha de Publicación: | 2017 |
| Descripción: | The determination of the spatial configuration of the compounds structures used in the production of drugs is of utmost importance due to the different physical characteristics that each have in their solid state and therefore the different qualities of each one for its use as pharmaceutical raw material. This study aimed to identify the polymorphic crystalline form of Etoricoxib raw material, a non-steroidal anti-inflammatory drug (NSAIDs) selective inhibitor of cyclooxygenase 2 (COX2) enzyme widely used in the present, which was done through four different instrumental analytical techniques: X-ray diffractometry, differential scanning calorimetry, thermogravimetry and infrared spectroscopy, comparing and studying the results obtained from the analysis with those found in the literature. Using the data obtained with these four techniques it was demonstrated that the study sample exists predominantly in the 1 anhydrous Etoricoxib form. |
| País: | Kérwá |
| Institución: | Universidad de Costa Rica |
| Repositorio: | Kérwá |
| Lenguaje: | Inglés |
| OAI Identifier: | oai:kerwa.ucr.ac.cr:10669/85905 |
| Acceso en línea: | http://saspublisher.com/sajp-62/ https://hdl.handle.net/10669/85905 |
| Palabra clave: | Differential scanning calorimetry Etoricoxib X-ray scattering pattern Infrared spectroscopy Pharmaceutical polymorphism Thermogravimetry |