Comparative study of the venoms of three subspecies of Lachesis muta (bushmaster) from Brazil, Colombia and Costa Rica

 

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Autores: Otero Patiño, Rafael, Furtado, María de Fátima, Gonçalves, Luís Roberto de Camargo, Núñez Rangel, Vitelbina, García, Martha E., Osorio, Raúl Guillermo, Romero, Marjorie, Gutiérrez, José María
格式: artículo original
Fecha de Publicación:1998
實物特徵:A comparative study was performed on the pharmacology and biochemistry of venoms from three subspecies of Lachesis muta (L. m. stenophrys, L. m. muta and L. m. rhombeata) from Brazil, Colombia and Costa Rica. All venoms induced lethal, hemorrhagic, edema-forming, myotoxic, coagulant and defibrinating effects, showing also proteolytic and indirect hemolytic activities. The venoms of L. m. stenophrys from Costa Rica and L. m. muta from Cascalheira, Brazil, had the highest lethal and hemorrhagic activities and the venom of L. m. rhombeata showed the highest coagulant activity, whereas no significant differences were observed in myotoxic and edema-forming activities at most of the time intervals studied. In addition, venoms showed similar electrophoretic patterns on SDS-polyacrylamide gel electrophoresis. In conclusion, despite quantitative differences in toxic and enzymatic activities, together with subtle variations in electrophoretic patterns, our results indicate that experimental envenomation by these venoms induce a qualitatively similar pathophysiological profile.
País:Kérwá
機構:Universidad de Costa Rica
Repositorio:Kérwá
OAI Identifier:oai:kerwa.ucr.ac.cr:10669/29444
在線閱讀:http://www.sciencedirect.com/science/article/pii/S0041010198000890
https://hdl.handle.net/10669/29444
Palabra clave:Animals
Brazil
Colombia
Costa Rica
Edema
Electrophoresis, Gel, Two-Dimensional
Fibrinolysis
Hemolysis
Hemorrhage
Infusions, Parenteral
Mice
Time Factors
Viperidae
Snake venom