Industrial Production and Quality Control of Snake Antivenoms
محفوظ في:
| المؤلفون: | , , , , , , , , |
|---|---|
| التنسيق: | capítulo de libro |
| تاريخ النشر: | 2014 |
| الوصف: | The production of snake antivenoms involves stages such as production of venom, immunization of animals to generate hyperimmune plasma, immunoglobulin purification, viral inactivation (or removal), and stabilization of the formulation. In order to manufacture products of satisfactory effectiveness and safety, antivenom design must be validated by preclinical and clinical studies. Moreover, during the industrial production, the quality of the products and of the entire manufacturing process (including management of clean rooms, production of water for injection, and sterilization or sanitization of the equipment) must be strictly evaluated. This chapter presents a practical description of the stages involved in the design, production, and quality control of snake antivenoms. |
| البلد: | Kérwá |
| المؤسسة: | Universidad de Costa Rica |
| Repositorio: | Kérwá |
| OAI Identifier: | oai:kerwa.ucr.ac.cr:10669/77323 |
| الوصول للمادة أونلاين: | https://link.springer.com/referenceworkentry/10.1007%2F978-94-007-6649-5_24-3 https://hdl.handle.net/10669/77323 |
| كلمة مفتاحية: | West Nile Virus Caprylic Acid Viral Inactivation Snake Species Snake venom 615.946 Venenos animales |