Antibody-dependent enhancement of toxicity of myotoxin II from Bothrops asper

 

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Detalles Bibliográficos
Autores: Sørensen, Christoffer V., Fernández, Julián, Adams, Anna Christina, Wildenauer, Helen H. K., Schoffelen, Sanne, Ledsgaard, Line, Pucca, Manuela Berto, Fiebig, Michael, Cerni, Felipe A., Tulika, Tulika, Voldborg, Bjørn, Karatt Vellatt, Aneesh, Morth, J. Preben, Ljungars, Anne, Grav, Lise M., Lomonte, Bruno, Laustsen, Andreas Hougaard
Formato: artículo original
Fecha de Publicación:2024
Descripción:Improved therapies are needed against snakebite envenoming, which kills and permanently disables thousands of people each year. Recently developed neutralizing monoclonal antibodies against several snake toxins have shown promise in preclinical rodent models. Here, we use phage display technology to discover a human monoclonal antibody and show that this antibody causes antibody-dependent enhancement of toxicity (ADET) of myotoxin II from the venomous pit viper, Bothrops asper, in a mouse model of envenoming that mimics a snakebite. While clinical ADET related to snake venom has not yet been reported in humans, this report of ADET of a toxin from the animal kingdom highlights the necessity of assessing even well-known antibody formats in representative preclinical models to evaluate their therapeutic utility against toxins or venoms. This is essential to avoid potential deleterious effects as exemplified in the present study.
País:Kérwá
Institución:Universidad de Costa Rica
Repositorio:Kérwá
Lenguaje:Inglés
OAI Identifier:oai:kerwa.ucr.ac.cr:10669/90794
Acceso en línea:https://www.nature.com/articles/s41467-023-42624-5
https://hdl.handle.net/10669/90794
Palabra clave:TOXICOLOGY
IMMUNOLOGY
DANGEROUS MATERIALS
REPTILES

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