Antibody-dependent enhancement of toxicity of myotoxin II from Bothrops asper

 

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Dades bibliogràfiques
Autors: Sørensen, Christoffer V., Fernández, Julián, Adams, Anna Christina, Wildenauer, Helen H. K., Schoffelen, Sanne, Ledsgaard, Line, Pucca, Manuela Berto, Fiebig, Michael, Cerni, Felipe A., Tulika, Tulika, Voldborg, Bjørn, Karatt Vellatt, Aneesh, Morth, J. Preben, Ljungars, Anne, Grav, Lise M., Lomonte, Bruno, Laustsen, Andreas Hougaard
Format: artículo original
Data de publicació:2024
Descripció:Improved therapies are needed against snakebite envenoming, which kills and permanently disables thousands of people each year. Recently developed neutralizing monoclonal antibodies against several snake toxins have shown promise in preclinical rodent models. Here, we use phage display technology to discover a human monoclonal antibody and show that this antibody causes antibody-dependent enhancement of toxicity (ADET) of myotoxin II from the venomous pit viper, Bothrops asper, in a mouse model of envenoming that mimics a snakebite. While clinical ADET related to snake venom has not yet been reported in humans, this report of ADET of a toxin from the animal kingdom highlights the necessity of assessing even well-known antibody formats in representative preclinical models to evaluate their therapeutic utility against toxins or venoms. This is essential to avoid potential deleterious effects as exemplified in the present study.
Pais:Kérwá
Institution:Universidad de Costa Rica
Repositorio:Kérwá
Idioma:Inglés
OAI Identifier:oai:kerwa.ucr.ac.cr:10669/90794
Accés en línia:https://www.nature.com/articles/s41467-023-42624-5
https://hdl.handle.net/10669/90794
Paraula clau:TOXICOLOGY
IMMUNOLOGY
DANGEROUS MATERIALS
REPTILES

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