Phospholipases A2: Unveiling the secrets of a functionally versatile group of snake venom toxins
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| Autors: | , |
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| Format: | artículo original |
| Data de publicació: | 2013 |
| Descripció: | Phospholipases A2 (PLA2s) are abundant components of snake venoms, where they play toxic and digestive roles. Despite having a similar three-dimensional structure, venom PLA2s exert an amazing variety of toxic and pharmacological effects, which include neurotoxic, myotoxic, hemolytic, edematogenic, hyperalgesic, pro-inflammatory, hypotensive, platelet-aggregation inhibitory, anticoagulant, cytotoxic, and bactericidal activities. Toxinologists have made significant contributions to deciphering the structure, molecular evolution, mechanisms of action, receptors, role of enzymatic activity for toxicity, structural determinants of toxicity and selectivity, and the impact of these enzymes in the overall pathophysiology of snakebite envenoming. The present work highlights some of the most relevant contributions in the study of venom PLA2s, including the personal accounts of the authors of these studies. |
| Pais: | Kérwá |
| Institution: | Universidad de Costa Rica |
| Repositorio: | Kérwá |
| OAI Identifier: | oai:kerwa.ucr.ac.cr:10669/30071 |
| Accés en línia: | http://www.sciencedirect.com/science/article/pii/S0041010112007490 https://hdl.handle.net/10669/30071 |
| Paraula clau: | Phospholipase A2 Snake venom Toxicity Neurotoxicity Myotoxicity Molecular evolution Receptors Enzymatic activity |