Anti-inflarnmatory activity of Urera baccifera (Urticaceae) in Sprague-Dawley rats
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| Autores: | , , , |
|---|---|
| Formato: | artículo original |
| Estado: | Versión publicada |
| Fecha de Publicación: | 1999 |
| Descripción: | On a preliminary test, anti-inflammatory and analgesic dose-related activities on rats were observed for the aqueous fraction of Urera baccifera; this extract was bioassay-guided fractionated and the final aqueous fraction was used according the ethnobotanical use. Carrageenan-induced edema (n=6), was used as an assay in the fractionating process. The anti-inflammatory and antinociceptive properties of the final aqueons fraction were studied using in vivo models. For the anti-inflammatory activity rat paw edema (n=6), pleurisy induced by carrageenan (n=6) and ear edema induced by topical croton oil (n=6) models were used, and tail-fIick test (n=6), abdominal constrictions induced by acetic acid (n=6), and formalin test (n=6), were used for the alltillociceptive activity. The tests perfonned showed an inhibition effeet on !eukocyte rnigration, and a reductioll on pleural exudate, as well as dose-dependant peripheral analgesic activity, al a range of 25-100 mglk:g i.p. The final aqueous fraction contains most of the anti-inflammatory activity of the plant U. baccifera. A possibJe mechanism of action is discussed and based on the results we conclude that this plant has a potential. for both anti-inflammalory and analgesic activity al the c1inical level. |
| País: | Portal de Revistas UCR |
| Institución: | Universidad de Costa Rica |
| Repositorio: | Portal de Revistas UCR |
| Lenguaje: | Inglés |
| OAI Identifier: | oai:portal.ucr.ac.cr:article/19085 |
| Acceso en línea: | https://revistas.ucr.ac.cr/index.php/rbt/article/view/19085 |
| Access Level: | acceso abierto |
| Palabra clave: | urera baccifera anti-illflammatory agent analgesic antinociceptive rat paw edema urticaceae |