Effect of leaves aqueous extract of Licania platypus (Hemsl.) Fritsch. On gastroprotection and gastrointestinal motility.

 

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Detalles Bibliográficos
Autores: Orozco Aguilar, Josué, Chavarría Rojas, Marianela, Sandí Flores, Jennifer, Alvarado Barboza, Gilbert, Cordero García, Eugenia, Morales Acuña, Juan Alberto, Retana Salazar, Axely, González Camacho, Sara
Formato: artículo original
Estado:Versión publicada
Fecha de Publicación:2018
Descripción:Licania platypus is a species widely distributed in tropical countries. Traditionally, it has been used in Central America for a variety of health problems, especially gastrointestinal problems. Aim: To investigate gastric antiulcer activity and gastrointestinal motility effect of Licania platypus leaves aqueous extract. Methods: Gastric lesions were induced by ethanol and indomethacin models; also other parameters were analyzed in pylorus-ligated model. Furthermore, was evaluated the effect on gastrointestinal motility phenol red. Results: Oral administration of aqueous extract (1000 mg/kg) significantly reduced the area of gastric lesions (p < 0,05) on both models. It was observed a significantly increased the gastric secretion volume and gastric mucus, whereas decreased total acidit and lipid peroxidation (p < 0,05). The aqueous extract of Licania platypus reduced the rate of gastric emptying (p < 0,05), but did not show any effect on intestinal transit. Conclusion: Licania platypus aqueous extract has a gastroprotective effect in different acute ulcer induction models and reducing the rate of gastric emptying. The activities proved in this study contribute ethnopharmacological toxicological knowledge attributed to Licania platypus.
País:Portal de Revistas UCR
Institución:Universidad de Costa Rica
Repositorio:Portal de Revistas UCR
Lenguaje:Español
OAI Identifier:oai:portal.ucr.ac.cr:article/34575
Acceso en línea:https://revistas.ucr.ac.cr/index.php/medica/article/view/34575
Access Level:acceso abierto
Palabra clave:ntiulcerosos
motilidad gastrointestinal
prostaglandinas
moco
antioxidantes