Effect of leaves aqueous extract of Licania platypus (Hemsl.) Fritsch. On gastroprotection and gastrointestinal motility.
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| Autors: | , , , , , , , |
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| Format: | artículo original |
| Estat: | Versión publicada |
| Data de publicació: | 2018 |
| Descripció: | Licania platypus is a species widely distributed in tropical countries. Traditionally, it has been used in Central America for a variety of health problems, especially gastrointestinal problems. Aim: To investigate gastric antiulcer activity and gastrointestinal motility effect of Licania platypus leaves aqueous extract. Methods: Gastric lesions were induced by ethanol and indomethacin models; also other parameters were analyzed in pylorus-ligated model. Furthermore, was evaluated the effect on gastrointestinal motility phenol red. Results: Oral administration of aqueous extract (1000 mg/kg) significantly reduced the area of gastric lesions (p < 0,05) on both models. It was observed a significantly increased the gastric secretion volume and gastric mucus, whereas decreased total acidit and lipid peroxidation (p < 0,05). The aqueous extract of Licania platypus reduced the rate of gastric emptying (p < 0,05), but did not show any effect on intestinal transit. Conclusion: Licania platypus aqueous extract has a gastroprotective effect in different acute ulcer induction models and reducing the rate of gastric emptying. The activities proved in this study contribute ethnopharmacological toxicological knowledge attributed to Licania platypus. |
| Pais: | Portal de Revistas UCR |
| Institution: | Universidad de Costa Rica |
| Repositorio: | Portal de Revistas UCR |
| Idioma: | Español |
| OAI Identifier: | oai:portal.ucr.ac.cr:article/34575 |
| Accés en línia: | https://revistas.ucr.ac.cr/index.php/medica/article/view/34575 |
| Paraula clau: | ntiulcerosos motilidad gastrointestinal prostaglandinas moco antioxidantes |