Actividad farmacológica del extracto acuoso de la madera de Quassia amara (Simarubaceae) en ratas y ratones albinos
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| Autores: | , , |
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| Formato: | artículo original |
| Estado: | Versión publicada |
| Fecha de Publicación: | 1996 |
| Descripción: | AH the assays were done with an aqueous preparation of dry wood from Quassia amara (Simarubaceae). For the hippocratic assay, 12 female SDN rats were used, with an average weight of 144 g and separated in three groups of four individuals each. The dose used were 500 mglkg and 1 000 mglkg and the control group received 0.5 mi of destilIed water. The extraet administration and the observation of the animals were done daily during nine days. Acute toxicity of the preparation was studied with 25 male NGP mice with an average weight of 20.13 g, in groups of five individuals per dose. The oral administration was carry out with the following doses: 250, 500, 750 and 1 000 mglkg, the control group received 0.5 mi of destilled water. No sigu of acute toxicity was observed at any dose. For the toxicity analysis via intraperitoneal inyeetion 15 male NGP mice were assigned to five groups (5 animals each) with doses of 500 and 1 000 mglkg and a control group with 0.5 mI of destilled water. The group with the dose of 500 mglkg, presented acute toxicity signs with a 24 hr recovery, and the 1 000 mglkg dose was letal to a 100% within 24 hr. The measuring of the peristaltie activity (movement of the intestinal content) were performed on 30 NGP male miee with an average weight of 22 g assigued to three groups of ten individual s each. One dose of 500 mglkg and 1 000 mglkg were orally adnñnistrated to each experimental group and 0.5 ml of destilled water to the control group. The marker used was activated carbon, orally supplied to every mice 30 min after the administration of the aqueous extract. The animals are decapitated and the measurement of the carbon motion in the small intestine was done after 30 min. Both dose increased the intestinal movement compared to the control group, but only the . 1 000 mglkg dose showed a statistically significant difference (p :S;O .05). |
| País: | Portal de Revistas UCR |
| Institución: | Universidad de Costa Rica |
| Repositorio: | Portal de Revistas UCR |
| Lenguaje: | Español |
| OAI Identifier: | oai:portal.ucr.ac.cr:article/21832 |
| Acceso en línea: | https://revistas.ucr.ac.cr/index.php/rbt/article/view/21832 |
| Access Level: | acceso abierto |