REVISIÓN SOBRE LA RELACIÓN DEL GENOTIPO PARA APOE4 Y EL DESARROLLO DE DEMENCIA TIPO ALZHEIMER
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| Autores: | , |
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| Formato: | artículo original |
| Estado: | Versión publicada |
| Fecha de Publicación: | 2011 |
| Descripción: | Introduction: Alzheimer’s disease is the mostcommon cause of dementia. Although there is anearly manifestation of 3 dominant autosomalgenes, they only explain between 1-2% of allcases. Efforts are made to establish the genetic risk for early diagnosis of the disease. Method:There are many scientific studies related to pre-vention, diagnosis and treatment of Alzheimer-type dementia. This review focuses on the pres-ence of the ApoE gene and its relationship to thedevelopment and progression of the disease.Conclusions: Alzheimer type dementia has mul-tifactorial origin; however, for late-onset casesthe presence of the ApoE4 genotype is an im-portant biomarker of risk factor. |
| País: | Portal de Revistas UCR |
| Institución: | Universidad de Costa Rica |
| Repositorio: | Portal de Revistas UCR |
| Lenguaje: | Español |
| OAI Identifier: | oai:portal.ucr.ac.cr:article/6516 |
| Acceso en línea: | https://revistas.ucr.ac.cr/index.php/clinica/article/view/6516 |
| Access Level: | acceso abierto |
| Palabra clave: | ampa apolipoproteina beta secretasa uno demencia alzheimer deterioro cognitivo leve lipoproteína de baja densidad receptor paralipoproteína de baja densidad n-metil-d-aspartato tomografía de emisión de positrones proteína precursora de amiloide apolipoprotein a beta-secretase alz-heimer's dementia mild cognitive impairment low density lipoprotein receptor for low density lipoprotein n methyl d aspartate positron emission tomography amyloid precursor protein presenilin gene brain |