Brucellin Aquilon: prueba diagn´ostica de Brucella en cerdos
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| Autor: | |
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| Format: | artículo original |
| Status: | Versión publicada |
| Datum izdanja: | 2026 |
| Opis: | The brucellae are gram-negative bacteria causing brucellosis, an infectious disease affecting a variety of mammals including domestic ruminants and swine. Brucella suis biovar 2 is presently restricted to continental Europe, where it represents an emerging problem causing abortions, infertility and a high economic impact in pig farms. Despite this, the EU is currently considered as officially free from swine brucellosis, and surveillance based solely on serological tests performed only for trade and as a routine surveillance in semen production. Current serological tests detect antibodies to the O-polysaccharide (O-PS) moiety of the Brucella smooth lipopolysaccharide (S-LPS), the dominant surface molecule present in all smooth brucellae. These O-PS tests include the Rose Bengal (RBT), Serum Agglutination (SAT), Complement Fixation (CFT), Fluorescence Polarization (FPA) and indirect or competitive Enzyme-linked Immunosorbent Assays (iELISA and cELISA, respectively). Despite being officially recommended for the diagnosis of swine brucellosis but these tests lack specificity to discriminate brucellosis from the FPSR caused by bacteria sharing O-PS epitopes with Brucella S-LPS, such as Yersinia enterocolitica O:9. Aquil´on & CZ Vaccines (Zendal Group), in cooperation with two international reference groups on Brucella research (CITA Arago´n and University of Navarra), has developed a new hypersensitivity skin test obtained from an O-PS free GMO of Brucella abortus: Brucellin Aquilon. Brucellin Aquilon has been specifically designed as a diagnostic test to differentiate Brucella-infected pigs (from 5 months of age) from the Brucella-free pigs having given false positive serological reactions (FPSR) in the Rose Bengal brucellosis serological test. |
| Zemlja: | Portal de Revistas UNA |
| Institucija: | Universidad Nacional de Costa Rica |
| Repositorio: | Portal de Revistas UNA |
| Jezik: | Inglés |
| OAI Identifier: | oai:www.revistas.una.ac.cr:article/23036 |
| Online pristup: | https://www.revistas.una.ac.cr/index.php/veterinaria/article/view/23036 |
| Ključna riječ: | Brucella Skin test Swine brucellosis Brucelin Aquilon Brucella suis |