Serological positivity against selected Flaviviruses and Alphaviruses in free-ranging bats and birds from Costa Rica evidence exposure to Arboviruses Seldom reported locally in humans

 

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Detalles Bibliográficos
Autores: Gamboa Solano, José Carlos, Romero, Luis Mario, Soto Garita, Claudio, Corrales Aguilar, Eugenia, Alfaro-Alarcon, Alejandro, Barrantes Murillo, Daniel Felipe, Piche-Ovares, María Marta
Formato: artículo
Fecha de Publicación:2022
Descripción:Abstract: Arboviruses have two ecological transmission cycles: sylvatic and urban. For some, the sylvatic cycle has not been thoroughly described in America. To study the role of wildlife in a putative sylvatic cycle, we sampled free-ranging bats and birds in two arbovirus endemic locations and analyzed them using molecular, serological, and histological methods. No current infection was detected, and no significant arbovirus-associated histological changes were observed. Neutralizing antibodies were detected against selected arboviruses. In bats, positivity in 34.95% for DENV-1, 16.26% for DENV-2, 5.69% for DENV-3, 4.87% for DENV-4, 2.43% for WNV, 4.87% for SLEV, 0.81% for YFV, 7.31% for EEEV, and 0.81% for VEEV was found. Antibodies against ZIKV were not detected. In birds, PRNT results were positive against WNV in 0.80%, SLEV in 5.64%, EEEV in 8.4%, and VEEV in 5.63%. An additional retrospective PRNT analysis was performed using bat samples from three additional DENV endemic sites resulting in a 3.27% prevalence for WNV and 1.63% for SLEV. Interestingly, one sample resulted unequivocally WNV positive confirmed by serum titration. These results suggest that free-ranging bats and birds are exposed to not currently reported hyperendemic-human infecting Flavivirus and Alphavirus; however, their role as reservoirs or hosts is still undetermined.
País:Repositorio UNA
Institución:Universidad Nacional de Costa Rica
Repositorio:Repositorio UNA
Lenguaje:Inglés
OAI Identifier:oai:null:11056/25570
Acceso en línea:http://hdl.handle.net/11056/25570
https://doi.org/10.3390/v14010093
Palabra clave:COSTA RICA
WILDLIFE
ANIMALES SILVESTRES
AVES
BIRDS
MURCIELAGO
BAT
ARBOVIRUS