Composite soy lecithin–decylpolyglucoside vesicles: A theoretical and experimental study
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| Autoři: | , , , , , , |
|---|---|
| Médium: | artículo |
| Datum vydání: | 2008 |
| Popis: | In the present work, vesicles made with soy lecithin and a commercial mixture of alkyl polyglucosides were prepared and characterized. Vesicles with a constant amount of soy lecithin and an increasing amount of a decylpolyglucoside surfactant, (OrNS10), were formulated and their physicochemical properties were studied with the aim to design a drug delivery system suitable for different applications. To this purpose, morphology, size distribution, ζ-potential and apparent viscosity of the prepared vesicles were studied. Vesicles were also characterized by using optical and light polarized microscopy, transmission electron microscopy and photon correlation spectroscopy. A stability study was also performed by checking mean size and ζ-potential value variation of the several formulations during 4 weeks. Moreover, theoretical advances on geometric and thermodynamic aspects related to lipid vesicle formation were applied to this study. © 2007 Elsevier B.V. All rights reserved. |
| Země: | Repositorio UNA |
| Instituce: | Universidad Nacional de Costa Rica |
| Repositorio: | Repositorio UNA |
| Jazyk: | Inglés |
| OAI Identifier: | oai:null:11056/23022 |
| On-line přístup: | http://hdl.handle.net/11056/23022 |
| Klíčové slovo: | VESICLES LECITHIN DECYLPOLYGLUCOSIDE Ζ-POTENTIAL APPARENT VISCOSITY QUITAR LECITINA VESICULAS |