Composite soy lecithin–decylpolyglucoside vesicles: A theoretical and experimental study

 

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Detalles Bibliográficos
Autores: Mura, S., Manconi, M., Madrigal Carballo, S., Sinico, C, Fadda, A.M, Vila, A.O, Molina, F
Formato: artículo
Fecha de Publicación:2008
Descripción:In the present work, vesicles made with soy lecithin and a commercial mixture of alkyl polyglucosides were prepared and characterized. Vesicles with a constant amount of soy lecithin and an increasing amount of a decylpolyglucoside surfactant, (OrNS10), were formulated and their physicochemical properties were studied with the aim to design a drug delivery system suitable for different applications. To this purpose, morphology, size distribution, ζ-potential and apparent viscosity of the prepared vesicles were studied. Vesicles were also characterized by using optical and light polarized microscopy, transmission electron microscopy and photon correlation spectroscopy. A stability study was also performed by checking mean size and ζ-potential value variation of the several formulations during 4 weeks. Moreover, theoretical advances on geometric and thermodynamic aspects related to lipid vesicle formation were applied to this study. © 2007 Elsevier B.V. All rights reserved.
País:Repositorio UNA
Institución:Universidad Nacional de Costa Rica
Repositorio:Repositorio UNA
Lenguaje:Inglés
OAI Identifier:oai:null:11056/23022
Acceso en línea:http://hdl.handle.net/11056/23022
Palabra clave:VESICLES
LECITHIN
DECYLPOLYGLUCOSIDE
Ζ-POTENTIAL
APPARENT VISCOSITY QUITAR
LECITINA
VESICULAS