Regulation of Brucella virulence by the two-component system BvrR/BvrS

 

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Detalles Bibliográficos
Autores: López-Goñi, Ignacio, Guzman-Verri, Caterina, Manterola, Lorea, Sola-Landa, Alberto, Moriyon, Ignacio, Moreno, Edgardo
Formato: artículo
Fecha de Publicación:2002
Descripción:The Brucella BvrR/BvrS two-component regulatory system is highly similar to the regulatory and sensory proteins of Sinorhizobium and Agrobacterium necessary for endosymbiosis and pathogenicity in plants, and very similar to a putative system present in the animal pathogen Bartonella. Mutations in the bvrR or bvrS genes hamper the penetration of B. abortus in non-phagocytic cells and impairs intracellular trafficking and virulence. In contrast to virulent Brucella, BvrR/BvrS mutants do not recruit small GTPases of the Rho subfamily required for actin polymerization and penetration to cells. Dysfunction of the BvrR/BvrS system alters the outer membrane permeability, the expression of several group 3 outer membrane proteins and the pattern of lipid A acylation. Constructs of virulent B. abortus chimeras containing heterologous LPS from the bvrS− mutant demonstrated an altered permeability to cationic peptides similar to that of the BvrR/BvrS mutants. We hypothesize that the Brucella BvrR/BvrS is a system devoted to the homeostasis of the outer membrane and, therefore in the interface for cell invasion and mounting the required structures for intracellular parasitism.
País:Repositorio UNA
Institución:Universidad Nacional de Costa Rica
Repositorio:Repositorio UNA
Lenguaje:Inglés
OAI Identifier:oai:null:11056/18428
Acceso en línea:http://hdl.handle.net/11056/18428
https://doi.org/10.1016/S0378-1135(02)00218-3
Palabra clave:BvrR/BvrS
BRUCELOSIS
BRUCELLA
VIRULENCE
PROTEÍNAS
MEMBRANAS CELULARES