Antimicrobial activities of Marcgraviaceae species and isolation of a naphthoquinone from Marcgravia nervosa (Marcgraviaceae)

 

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Autoři: Carballo Arce, Ana Francis, Chieu Anh, Kim Ta, do Nascimento Rocha, Marco Eduardo, Rui, Liu, Harmsen, Irene, Mogg, Christopher, Otárola-Rojas, Marco, Garcia, Mario, Sánchez Vindas, Pablo, Poveda, Luis, Rajagopal Subramaniam, Smith, Myron, Coelho Kaplan, Maria Auxiliadora, Figueiredo, Maria Raquel, Durst, Tony, Arnason, John
Médium: artículo
Datum vydání:2015
Popis:The Marcgraviaceae is a neotropical plant family of lianas and shrubs distributed throughout Central and South America, mainly in evergreen and semi-evergreen tropical forests. In this study, extracts of 12 Marcgraviaceae species were assessed for inhibition of bacterial quorum sensing (QS) in Chromobacterium violaceum, bacterial biofilm formation in Pseudomonas aeruginosa PA14, and fungal growth in Saccharomyces cerevisiae. Six species showed promising inhibitory activities in at least one of the three bioassays (Marcgravia nervosa Triana & Planch., Marcgravia polyantha Delp., Marcgravia schippii Standl., Marcgraviastrum subsessile (Benth.) Bedell, Schwartzia brasiliensis (Choisy) Bedell ex Gir-Cañas, and Schwartzia costaricensis (Gilg.) Bedell). Analyses of the crude extract of the leaves of Marcgravia nervosa using HPLC–APCI–MS showed the presence of five pentacyclic triterpenes: ursolic acid (2), betulinic acid (3), α–amyrin (4), β–amyrin (5), lupeol (6). Bioassay-guided fractionation of this plant resulted in the isolation and identification of 2-methoxy-1,4-naphthoquinone (1) as the active principle with a minimum inhibitory concentration (MIC) of 85–100 μmol·L−1 against Saccharomyces cerevisiae BY4741 (haploid) and BY4743 (diploid).
Země:Repositorio UNA
Instituce:Universidad Nacional de Costa Rica
Repositorio:Repositorio UNA
Jazyk:Inglés
OAI Identifier:oai:null:11056/22855
On-line přístup:http://hdl.handle.net/11056/22855
https://doi.org/10.1139/cjb-2015-0038
Klíčové slovo:MARCGRAVIACEAE
MARCGRAVIA NERVOSA
QUORUM SENSING
NAPHTHOQUINONE
PLANTAS
BOSQUES TROPICALES
ARBUSTOS
BIOFILM
ANTIFUNGAL