Synthesis and Biological Activity of New Antifungal Compounds: A Preliminary Study

 

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Autores: Cabezas Pizarro, Jorge A., Brenes Jiménez, José Ángel, Gross, Norma Teresa, Arias Echandi, María Laura
格式: artículo original
Fecha de Publicación:2018
实物特征:In the present study, we synthesized three 1,3-enynes from their corresponding aldehydes. They exhibited antifungal activity, which was evaluated against Trichophyton rubrum, the most common dermatophyte responsible for nail infection. The biological activity of these synthetic enynes was compared to terbinafine and ciclopirox olamine, two common antimycotic drugs used to treat nail infections caused by this pathogen. Two of these compounds showed an inhibitory effect similar to terbinafine and cilopirox olamine, when tested against over eleven different T. rubrum strains, including ATCC 28188 strain and ten different clinical isolates, two already classified as multitreated.
País:Kérwá
机构:Universidad de Costa Rica
Repositorio:Kérwá
语言:Inglés
OAI Identifier:oai:kerwa.ucr.ac.cr:10669/88357
在线阅读:http://ijmcr.com/synthesis-and-biological-activity-of-new-antifungal-compounds-a-preliminary-study/
https://hdl.handle.net/10669/88357
Palabra clave:CHEMISTRY
CHEMICAL EFFECTS
SKIN DISEASES
MICROBIOLOGY