Synthesis and Biological Activity of New Antifungal Compounds: A Preliminary Study
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| Nhiều tác giả: | , , , |
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| Định dạng: | artículo original |
| Ngày xuất bản: | 2018 |
| Miêu tả: | In the present study, we synthesized three 1,3-enynes from their corresponding aldehydes. They exhibited antifungal activity, which was evaluated against Trichophyton rubrum, the most common dermatophyte responsible for nail infection. The biological activity of these synthetic enynes was compared to terbinafine and ciclopirox olamine, two common antimycotic drugs used to treat nail infections caused by this pathogen. Two of these compounds showed an inhibitory effect similar to terbinafine and cilopirox olamine, when tested against over eleven different T. rubrum strains, including ATCC 28188 strain and ten different clinical isolates, two already classified as multitreated. |
| Quốc gia: | Kérwá |
| Tổ chức giáo dục: | Universidad de Costa Rica |
| Repositorio: | Kérwá |
| Ngôn ngữ: | Inglés |
| OAI Identifier: | oai:kerwa.ucr.ac.cr:10669/88357 |
| Truy cập trực tuyến: | http://ijmcr.com/synthesis-and-biological-activity-of-new-antifungal-compounds-a-preliminary-study/ https://hdl.handle.net/10669/88357 |
| Từ khóa: | CHEMISTRY CHEMICAL EFFECTS SKIN DISEASES MICROBIOLOGY |