A new muscle damaging toxin, myotoxin II, from the venom of the snake Bothrops asper (terciopelo)
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| Autores: | , |
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| Formato: | artículo original |
| Fecha de Publicación: | 1989 |
| Descripción: | A new muscle damaging toxin, myotoxin II, was purified from the venom of Bothrops asper by ion-exchange chromatography on CMSephadex C-25. The toxin is a dimeric, basic protein with a monomer mol.wt of 13,341, according to the amino acid composition, and 16,000 on the basis of SDS-polyacrylamide gel electrophoretic mobility . It has a high number of aspartate and lysine residues, as well as of hydrophobic amino acids. Upon i.m. injection into mice, the toxin induces myonecrosis and increase in serum creatine kinase levels . In addition, myotoxin II induces edema in the mouse foot pad. Immunochemical tests, mol.wt, and amino acid composition indicate a high degree ofhomology between myotoxin II and a previously characterized myotoxin from this venom, myotoxin I. However, in contrast to myotoxin I, myotoxin II lacks phospholipase A2 and anticoagulant activities in vitro. |
| País: | Kérwá |
| Institución: | Universidad de Costa Rica |
| Repositorio: | Kérwá |
| OAI Identifier: | oai:kerwa.ucr.ac.cr:10669/72948 |
| Acceso en línea: | http://www.sciencedirect.com/science/article/pii/0041010189900391 https://hdl.handle.net/10669/72948 |
| Palabra clave: | myotoxin Bothrops Snake venom |