Ability of the phospholipase A2 inhibitor Varespladib to abrogate or delay lethality induced by neurotoxic snake venoms
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| Autori: | , , , |
|---|---|
| Data di pubblicazione: | 2020 |
| Descrizione: | This study investigated the ability of the phospholipase A2 (PLA2) inhibitor Varespladib (LY315920) and its oral prodrug, methyl-Varespladib (LY333013), to abrogate or delay the lethality induced by potent neurotoxic snake venoms in a mouse model. The venoms tested were from Oxyuranus scutellatus, Notechis scutatus, Bungarus multicinctus, and Crotalus durissus terrificus, all known for having potent neurotoxic PLA2s. |
| Stato: | Kérwá |
| Istituzione: | Universidad de Costa Rica |
| Repositorio: | Kérwá |
| Lingua: | Inglés |
| OAI Identifier: | oai:kerwa.ucr.ac.cr:10669/103433 |
| Accesso online: | https://hdl.handle.net/10669/103433 https://doi.org/10.1016/j.toxicon.2019.10.069 |
| Keyword: | Neurotoxic venom Presynaptic PLA2s Antidote Lethality Varespladib (LY315920) |