Snakebite envenoming in French Guiana: assessment of the preclinical efficacy against the venom of Bothrops atrox of two polyspecific antivenoms

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Autores:	Resiere, Dabor, Villalta Arrieta, Mauren, Arias Oviedo, Ana Silvia, Kallel, Hatem, Nèviére, Rémi, Vidal, Nicolas, Mehdaoui, Hossein, Gutiérrez, José María
格式:	artículo original
Fecha de Publicación:	2020
實物特徵:	Snakebite envenoming is a relevant public health problem in French Guiana, and Bothrops atrox is responsible for the vast majority of envenomings in this overseas French territory. The preclinical efficacy of freeze-dried antivenoms manufactured in Costa Rica (Polival-ICP®) and Mexico (Antivipmyn Tri®) was assessed against the lethal, hemorrhagic, in vitro coagulant, and myotoxic effects of Bothrops atrox venom from French Guiana. Antivenoms differ in protein concentration and in the type of active principle (IgG and F (ab’)2, respectively). Polival-ICP® showed significantly higher neutralizing activity against lethal, hemorrhagic and in vitro coagulant activities of the venom. Antivenoms neutralized myotoxic effect to a similar extent. In the case of lethal activity, Antivipmyn Tri® did not neutralize the effect at the highest antivenom level tested (1 mg venom/mL antivenom).
País:	Kérwá
機構:	Universidad de Costa Rica
Repositorio:	Kérwá
語言:	Inglés
OAI Identifier:	oai:kerwa.ucr.ac.cr:10669/103873
在線閱讀:	https://hdl.handle.net/10669/103873 https://doi.org/10.1016/j.toxicon.2019.11.001
Palabra clave:	snake venoms French Guiana antivenom neutralization preclinical efficacy Polival-ICP® Antivipmyn Tri®