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Molecular epidemiology of Clostridium difficile infection in a Brazilian cancer hospital

 

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Autoren: Leite Costa, Cecília, Barreto Mano de Carvalho, Cibele, Holanda González, Rafael, Cavalcante Gifoni, Markus Andret, Ribeiro, Ronaldo de Albuquerque, Quesada Gómez, Carlos, de Castro Brito, Gerly Anne
Format: artículo original
Publikationsdatum:2017
Beschreibung:Clostridium difficile is a Gram-positive spore forming anaerobic bacterium and the main cause of healthcare-associated diarrhea. This study aimed to perform the phenotypic characterization and molecular typing of Clostridium difficile isolates among patients at a cancer hospital in Brazil. During 18 months, 48 diarrheic fecal samples were collected, of these 48% were positive in either one or both of the performed tests: detection of toxins A/B and culture. Clostridium difficile was recovered from four samples (17%). All strains carried toxin A and B genes, and the isolates belonged to PCR-ribotype 014/020, PGFE-type NAP4 and toxinotype XVIII. On the other hand, one isolate belonged to a novel PCR-ribotype, and PFGE-type, likewise to toxinotype IXb. The isolates showed susceptibility to metronidazole, vancomycin and moxifloxacin, and were resistant to ciprofloxacin. Finally, the findings indicate high positivity between the samples tested, suggesting an expressive importance of this infection, including detection of a novel ribotype/PFGE-type of Clostridium difficile, and show for the first time the detection of community-associated Clostridium difficile infection (CA-CDI) in these patients in Northeast Brazil. These data emphasize the importance to a better understanding of the epidemiological situation of this infection in Brazilian hospitals.
Land:Kérwá
Institution:Universidad de Costa Rica
Repositorio:Kérwá
Sprache:Inglés
OAI Identifier:oai:kerwa.ucr.ac.cr:10669/90814
Online Zugang:https://hdl.handle.net/10669/90814
Stichwort:EPIDEMIOLOGY
BACTERIA
HOSPITALS
CANCER
PATIENTS
BRAZIL