Inhibition of Tumor Cells Interacting with Stromal Cells by Xanthones Isolated from a Costa Rican Penicillium sp.
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| Autores: | , , , , , |
|---|---|
| Formato: | artículo original |
| Fecha de Publicación: | 2012 |
| Descripción: | CR1642D, an endophytic isolate of Penicillium sp. collected from a Costa Rican rainforest, was identified through a high-throughput approach to identify natural products with enhanced antitumor activity in the context of tumor–stromal interactions. Bioassay-guided separation led to the identification of five xanthones (1–5) from CR1642D. The structures of the xanthone dimer penexanthone A (1) and monomer penexanthone B (2) were elucidated on the basis of spectroscopic analyses, including 2D NMR experiments. All of the compounds were tested against a panel of tumor cell lines in the presence and absence of bone marrow stromal cells. Compound 3 was the most active, with IC50 values of 1–17 μM, and its activity was enhanced 2-fold against tumor cell line RPMI8226 in the presence of stromal cells (IC50 1.2 μM, but 2.4 μM without stromal cells). |
| País: | Kérwá |
| Institución: | Universidad de Costa Rica |
| Repositorio: | Kérwá |
| Lenguaje: | Inglés |
| OAI Identifier: | oai:kerwa.ucr.ac.cr:10669/87967 |
| Acceso en línea: | https://pubs.acs.org/doi/10.1021/np2009863 https://hdl.handle.net/10669/87967 |
| Palabra clave: | Alkyls Aromatic compounds Monomers Xanthones CELLS COSTA RICA |