Sekikaic Acid and Lobaric Acid Target a Dynamic Interface of the Coactivator CBP/p300

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Bibliographic Details
Authors:	Majmudar, Chinmay Y., Højfeldt, Jonas W., Arevang, Carl J., Pomerantz, William C., Gagnon, Jessica K., Schultz, Pamela J., Cesa, Laura C., Doss, Conor H., Rowe, Steven P., Vásquez Chaves, Víctor, Tamayo Castillo, Giselle, Cierpicki, Tomasz, Brooks, Charles L. III, Sherman, David H., Mapp, Anna K.
Format:	artículo original
Publication Date:	2012
Description:	Although there have been recent notable successes in thediscovery of ligands that target stable, high-affinity protein-protein interactions (PPIs), the transient and moderateaffinity PPIs that underpin many fundamental cellularprocesses have proven to be far less tractable for liganddiscovery.[1]Prime examples of this are the dynamic com-plexes formed between DNA-bound transcriptional activa-tors and coactivators that are part of eukaryotic transcriptioninitiation.
Country:	Kérwá
Institution:	Universidad de Costa Rica
Repositorio:	Kérwá
Language:	Inglés
OAI Identifier:	oai:kerwa.ucr.ac.cr:10669/87973
Online Access:	https://onlinelibrary.wiley.com/doi/10.1002/anie.201206815 https://hdl.handle.net/10669/87973
Keyword:	Coaktivatoren Depside Inhibitoren Protein-Protein-Wechselwirkungen Sekikasäure