Sekikaic Acid and Lobaric Acid Target a Dynamic Interface of the Coactivator CBP/p300

Αποθηκεύτηκε σε:

Λεπτομέρειες βιβλιογραφικής εγγραφής
Συγγραφείς:	Majmudar, Chinmay Y., Højfeldt, Jonas W., Arevang, Carl J., Pomerantz, William C., Gagnon, Jessica K., Schultz, Pamela J., Cesa, Laura C., Doss, Conor H., Rowe, Steven P., Vásquez Chaves, Víctor, Tamayo Castillo, Giselle, Cierpicki, Tomasz, Brooks, Charles L. III, Sherman, David H., Mapp, Anna K.
Μορφή:	artículo original
Ημερομηνία έκδοσης:	2012
Περιγραφή:	Although there have been recent notable successes in thediscovery of ligands that target stable, high-affinity protein-protein interactions (PPIs), the transient and moderateaffinity PPIs that underpin many fundamental cellularprocesses have proven to be far less tractable for liganddiscovery.[1]Prime examples of this are the dynamic com-plexes formed between DNA-bound transcriptional activa-tors and coactivators that are part of eukaryotic transcriptioninitiation.
Χώρα:	Kérwá
Ίδρυμα:	Universidad de Costa Rica
Repositorio:	Kérwá
Γλώσσα:	Inglés
OAI Identifier:	oai:kerwa.ucr.ac.cr:10669/87973
Διαθέσιμο Online:	https://onlinelibrary.wiley.com/doi/10.1002/anie.201206815 https://hdl.handle.net/10669/87973
Λέξη-Κλειδί :	Coaktivatoren Depside Inhibitoren Protein-Protein-Wechselwirkungen Sekikasäure