Sekikaic Acid and Lobaric Acid Target a Dynamic Interface of the Coactivator CBP/p300

 

محفوظ في:
التفاصيل البيبلوغرافية
المؤلفون: Majmudar, Chinmay Y., Højfeldt, Jonas W., Arevang, Carl J., Pomerantz, William C., Gagnon, Jessica K., Schultz, Pamela J., Cesa, Laura C., Doss, Conor H., Rowe, Steven P., Vásquez Chaves, Víctor, Tamayo Castillo, Giselle, Cierpicki, Tomasz, Brooks, Charles L. III, Sherman, David H., Mapp, Anna K.
التنسيق: artículo original
تاريخ النشر:2012
الوصف:Although there have been recent notable successes in thediscovery of ligands that target stable, high-affinity protein-protein interactions (PPIs), the transient and moderateaffinity PPIs that underpin many fundamental cellularprocesses have proven to be far less tractable for liganddiscovery.[1]Prime examples of this are the dynamic com-plexes formed between DNA-bound transcriptional activa-tors and coactivators that are part of eukaryotic transcriptioninitiation.
البلد:Kérwá
المؤسسة:Universidad de Costa Rica
Repositorio:Kérwá
اللغة:Inglés
OAI Identifier:oai:kerwa.ucr.ac.cr:10669/87973
الوصول للمادة أونلاين:https://onlinelibrary.wiley.com/doi/10.1002/anie.201206815
https://hdl.handle.net/10669/87973
كلمة مفتاحية:Coaktivatoren
Depside
Inhibitoren
Protein-Protein-Wechselwirkungen
Sekikasäure

مواد مشابهة