Sekikaic Acid and Lobaric Acid Target a Dynamic Interface of the Coactivator CBP/p300
में बचाया:
लेखकों: | , , , , , , , , , , , , , , |
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स्वरूप: | artículo original |
प्रकाशन तिथि: | 2012 |
विवरण: | Although there have been recent notable successes in thediscovery of ligands that target stable, high-affinity protein-protein interactions (PPIs), the transient and moderateaffinity PPIs that underpin many fundamental cellularprocesses have proven to be far less tractable for liganddiscovery.[1]Prime examples of this are the dynamic com-plexes formed between DNA-bound transcriptional activa-tors and coactivators that are part of eukaryotic transcriptioninitiation. |
देश: | Kérwá |
संस्थान: | Universidad de Costa Rica |
Repositorio: | Kérwá |
भाषा: | Inglés |
OAI Identifier: | oai:kerwa.ucr.ac.cr:10669/87973 |
ऑनलाइन पहुंच: | https://onlinelibrary.wiley.com/doi/10.1002/anie.201206815 https://hdl.handle.net/10669/87973 |
Access Level: | acceso abierto |
संकेत शब्द: | Coaktivatoren Depside Inhibitoren Protein-Protein-Wechselwirkungen Sekikasäure |