Sekikaic Acid and Lobaric Acid Target a Dynamic Interface of the Coactivator CBP/p300

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Bibliografski detalji
Autori:	Majmudar, Chinmay Y., Højfeldt, Jonas W., Arevang, Carl J., Pomerantz, William C., Gagnon, Jessica K., Schultz, Pamela J., Cesa, Laura C., Doss, Conor H., Rowe, Steven P., Vásquez Chaves, Víctor, Tamayo Castillo, Giselle, Cierpicki, Tomasz, Brooks, Charles L. III, Sherman, David H., Mapp, Anna K.
Format:	artículo original
Datum izdanja:	2012
Opis:	Although there have been recent notable successes in thediscovery of ligands that target stable, high-affinity protein-protein interactions (PPIs), the transient and moderateaffinity PPIs that underpin many fundamental cellularprocesses have proven to be far less tractable for liganddiscovery.[1]Prime examples of this are the dynamic com-plexes formed between DNA-bound transcriptional activa-tors and coactivators that are part of eukaryotic transcriptioninitiation.
Zemlja:	Kérwá
Institucija:	Universidad de Costa Rica
Repositorio:	Kérwá
Jezik:	Inglés
OAI Identifier:	oai:kerwa.ucr.ac.cr:10669/87973
Online pristup:	https://onlinelibrary.wiley.com/doi/10.1002/anie.201206815 https://hdl.handle.net/10669/87973
Ključna riječ:	Coaktivatoren Depside Inhibitoren Protein-Protein-Wechselwirkungen Sekikasäure