Sekikaic Acid and Lobaric Acid Target a Dynamic Interface of the Coactivator CBP/p300

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書誌詳細
著者:	Majmudar, Chinmay Y., Højfeldt, Jonas W., Arevang, Carl J., Pomerantz, William C., Gagnon, Jessica K., Schultz, Pamela J., Cesa, Laura C., Doss, Conor H., Rowe, Steven P., Vásquez Chaves, Víctor, Tamayo Castillo, Giselle, Cierpicki, Tomasz, Brooks, Charles L. III, Sherman, David H., Mapp, Anna K.
フォーマット:	artículo original
出版日付:	2012
その他の書誌記述:	Although there have been recent notable successes in thediscovery of ligands that target stable, high-affinity protein-protein interactions (PPIs), the transient and moderateaffinity PPIs that underpin many fundamental cellularprocesses have proven to be far less tractable for liganddiscovery.[1]Prime examples of this are the dynamic com-plexes formed between DNA-bound transcriptional activa-tors and coactivators that are part of eukaryotic transcriptioninitiation.
国:	Kérwá
機関:	Universidad de Costa Rica
Repositorio:	Kérwá
言語:	Inglés
OAI Identifier:	oai:kerwa.ucr.ac.cr:10669/87973
オンライン･アクセス:	https://onlinelibrary.wiley.com/doi/10.1002/anie.201206815 https://hdl.handle.net/10669/87973
キーワード:	Coaktivatoren Depside Inhibitoren Protein-Protein-Wechselwirkungen Sekikasäure