Sekikaic Acid and Lobaric Acid Target a Dynamic Interface of the Coactivator CBP/p300

 

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Bibliografische gegevens
Auteurs: Majmudar, Chinmay Y., Højfeldt, Jonas W., Arevang, Carl J., Pomerantz, William C., Gagnon, Jessica K., Schultz, Pamela J., Cesa, Laura C., Doss, Conor H., Rowe, Steven P., Vásquez Chaves, Víctor, Tamayo Castillo, Giselle, Cierpicki, Tomasz, Brooks, Charles L. III, Sherman, David H., Mapp, Anna K.
Formaat: artículo original
Publicatiedatum:2012
Omschrijving:Although there have been recent notable successes in thediscovery of ligands that target stable, high-affinity protein-protein interactions (PPIs), the transient and moderateaffinity PPIs that underpin many fundamental cellularprocesses have proven to be far less tractable for liganddiscovery.[1]Prime examples of this are the dynamic com-plexes formed between DNA-bound transcriptional activa-tors and coactivators that are part of eukaryotic transcriptioninitiation.
Land:Kérwá
Instelling:Universidad de Costa Rica
Repositorio:Kérwá
Taal:Inglés
OAI Identifier:oai:kerwa.ucr.ac.cr:10669/87973
Online toegang:https://onlinelibrary.wiley.com/doi/10.1002/anie.201206815
https://hdl.handle.net/10669/87973
Keyword:Coaktivatoren
Depside
Inhibitoren
Protein-Protein-Wechselwirkungen
Sekikasäure

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