Sekikaic Acid and Lobaric Acid Target a Dynamic Interface of the Coactivator CBP/p300

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Nhiều tác giả:	Majmudar, Chinmay Y., Højfeldt, Jonas W., Arevang, Carl J., Pomerantz, William C., Gagnon, Jessica K., Schultz, Pamela J., Cesa, Laura C., Doss, Conor H., Rowe, Steven P., Vásquez Chaves, Víctor, Tamayo Castillo, Giselle, Cierpicki, Tomasz, Brooks, Charles L. III, Sherman, David H., Mapp, Anna K.
Định dạng:	artículo original
Ngày xuất bản:	2012
Miêu tả:	Although there have been recent notable successes in thediscovery of ligands that target stable, high-affinity protein-protein interactions (PPIs), the transient and moderateaffinity PPIs that underpin many fundamental cellularprocesses have proven to be far less tractable for liganddiscovery.[1]Prime examples of this are the dynamic com-plexes formed between DNA-bound transcriptional activa-tors and coactivators that are part of eukaryotic transcriptioninitiation.
Quốc gia:	Kérwá
Tổ chức giáo dục:	Universidad de Costa Rica
Repositorio:	Kérwá
Ngôn ngữ:	Inglés
OAI Identifier:	oai:kerwa.ucr.ac.cr:10669/87973
Truy cập trực tuyến:	https://onlinelibrary.wiley.com/doi/10.1002/anie.201206815 https://hdl.handle.net/10669/87973
Từ khóa:	Coaktivatoren Depside Inhibitoren Protein-Protein-Wechselwirkungen Sekikasäure