Discovery of nicoyamycin A, an inhibitor of uropathogenic Escherichia coli growth in low iron environments
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| Autores: | , , , , , , , |
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| Formato: | artículo original |
| Fecha de Publicación: | 2017 |
| Descripción: | High-throughput screening and activity-guided purification identified nicoyamycin A, a natural product comprised of an uncommon 3-methyl-1,4-dioxane ring incorporated into a desferrioxamine-like backbone via a spiroaminal linkage. Nicoyamycin A potently inhibits uropathogenic Escherichia coli growth in low iron medium, a promising step toward developing novel antibiotics to treat recalcitrant bacterial infections. |
| País: | Kérwá |
| Institución: | Universidad de Costa Rica |
| Repositorio: | Kérwá |
| OAI Identifier: | oai:kerwa.ucr.ac.cr:10669/80612 |
| Acceso en línea: | https://pubs.rsc.org/en/content/articlelanding/2017/cc/c7cc07732g#!divAbstract https://hdl.handle.net/10669/80612 |
| Palabra clave: | Nicoyamycin A Escherichia coli Inhibitor Antibiotics Bacterial infections |