Discovery of nicoyamycin A, an inhibitor of uropathogenic Escherichia coli growth in low iron environments

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Bibliographic Details
Authors:	Mike, Laura A., Tripathi, Ashootosh, Blankenship, Connor M., Saluk, Alyssa, Schultz, Pamela J., Tamayo Castillo, Giselle, Sherman, David H., Mobley, Harry L. T.
Format:	artículo original
Publication Date:	2017
Description:	High-throughput screening and activity-guided purification identified nicoyamycin A, a natural product comprised of an uncommon 3-methyl-1,4-dioxane ring incorporated into a desferrioxamine-like backbone via a spiroaminal linkage. Nicoyamycin A potently inhibits uropathogenic Escherichia coli growth in low iron medium, a promising step toward developing novel antibiotics to treat recalcitrant bacterial infections.
Country:	Kérwá
Institution:	Universidad de Costa Rica
Repositorio:	Kérwá
OAI Identifier:	oai:kerwa.ucr.ac.cr:10669/80612
Online Access:	https://pubs.rsc.org/en/content/articlelanding/2017/cc/c7cc07732g#!divAbstract https://hdl.handle.net/10669/80612
Keyword:	Nicoyamycin A Escherichia coli Inhibitor Antibiotics Bacterial infections