Palladium-Catalyzed One-Pot Conversion of Aldehydes and Ketones into 4‑Substituted Homopropargyl Alcohols and 5‑En-3-yn-1-ols
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| المؤلفون: | , |
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| التنسيق: | artículo original |
| تاريخ النشر: | 2017 |
| الوصف: | Sequential treatment of 2,3-dichloropropene with magnesium and n-BuLi generated the equivalent of 1,3- dilithiopropyne, which adds regiospecifically to aldehydes and ketones to produce homopropargyl alcohols. The lithium acetylide intermediate formed in this protocol can be further reacted with aromatic and vinyl halides, under palladium catalysis, to produce 4-substituted homopropargyl alcohols and 5-en-3-yn-1-ols, respectively, in one-pot with good overall yields. |
| البلد: | Kérwá |
| المؤسسة: | Universidad de Costa Rica |
| Repositorio: | Kérwá |
| اللغة: | Inglés |
| OAI Identifier: | oai:kerwa.ucr.ac.cr:10669/87985 |
| الوصول للمادة أونلاين: | https://pubs.acs.org/doi/10.1021/acs.joc.7b01529 https://hdl.handle.net/10669/87985 |
| كلمة مفتاحية: | Alcohols Allenes Aromatic compounds Hydrocarbons Palladium |