Preclinical assessment of the neutralizing capacity of antivenoms produced in six Latin American countries against medically-relevant Bothrops snake venoms

 

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Autores: Segura Ruiz, Álvaro, Castillo, M. C., Núñez Rangel, Vitelbina, Yarlequé, A., Gonçalves, Luís Roberto de Camargo, Villalta Arrieta, Mauren, Bonilla, César, Herrera Vega, María, Fernández, M., Yano, M. Y., Araújo, H. P., Boller, M. A. A., León, P., Sano Martins, I. S., Gómez, A., Fernández, Gil Patrick, Geoghegan, Patricia, Higashi, Hisako Gondo, León Montero, Guillermo, Gutiérrez, José María, Tintaya, Benigno
格式: artículo original
Fecha de Publicación:2010
实物特征:Species of the genus Bothrops induce the vast majority of snakebite envenomings in Latin America. A preclinical study was performed in the context of a regional network of public laboratories involved in the production, quality control and development of antivenoms in Latin America. The ability of seven polyspecific antivenoms, produced in Argentina, Brazil, Peru, Bolivia, Colombia and Costa Rica, to neutralize lethal, hemorrhagic, coagulant, defibrinogenating and myotoxic activities of the venoms of Bothrops neuwiedi (diporus) (Argentina), Bothrops jararaca (Brazil), B. neuwiedi (mattogrossensis) (Bolivia), Bothrops atrox (Peru and Colombia) and Bothrops asper (Costa Rica) was assessed using standard laboratory tests. Despite differences in the venom mixtures used in the immunization of animals for the production of these antivenoms, a pattern of extensive cross-neutralization was observed between these antivenoms and all the venoms tested, with quantitative differences in the values of effective doses. This study reveals the capacity of these antivenoms to neutralize, in preclinical tests, homologous and heterologous Bothrops venoms in Central and South America, and also highlight quantitative differences in the values of Median Effective Doses (ED50s) between the various antivenoms.
País:Kérwá
机构:Universidad de Costa Rica
Repositorio:Kérwá
OAI Identifier:oai:kerwa.ucr.ac.cr:10669/29321
在线阅读:http://www.sciencedirect.com/science/article/pii/S0041010110002576
https://hdl.handle.net/10669/29321
Palabra clave:Bothrops
Antivenom
Neutralization
Preclinical
Snake venom