Neutralization of myotoxic phospholipases A2 from the venom of the snake Bothrops asper by monoclonal antibodies
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| Авторы: | , , , |
|---|---|
| Формат: | artículo original |
| Дата публикации: | 1992 |
| Описание: | The neutralization of two myotoxic phospholipases A2 from the venom of Bothrops asper, myotoxins I and II, by two murine monoclonal antibodies is reported. The monoclonal antibodies, MAb-3 and Mab-4, recognize different epitopes of the toxin. Both antibodies completely neutralized myotoxic activity of myotoxin I and crude venom. MAb-3 also completely neutralized myotoxic activity of myotoxin II, a lysine-49 phospholipase A2 isoform, whereas MAb-4 neutralized this toxin only partially. MAb-3 neutralized myotoxin II at a molar ratio of 1:1, showing a higher efficiency than affinity-purified polyclonal antibodies. A dissociation of myotoxic and enzymatic activities of myotoxin I was observed with both monoclonal antibodies. |
| Страна: | Kérwá |
| Институт: | Universidad de Costa Rica |
| Repositorio: | Kérwá |
| OAI Identifier: | oai:kerwa.ucr.ac.cr:10669/29173 |
| Online-ссылка: | https://hdl.handle.net/10669/29173 |
| Ключевое слово: | Animals Antibodies Monoclonal Crotalid Venoms Epitopes Group II Phospholipases A2 Mice Inbred BALB C Neurotoxins Neutralization Tests Phospholipases A Phospholipases A2 Reptilian Proteins |