Antibody neutralization of a myotoxin from the venom of Bothrops asper (terciopelo)
সংরক্ষণ করুন:
| লেখক: | , , , |
|---|---|
| বিন্যাস: | artículo original |
| প্রকাশনার তারিখ: | 1987 |
| বিবরন: | Neutralization of biological activities of B. asper myotoxin by a monospecific anti-myotoxin rabbit serum and polyvalent antivenom was studied. Both antisera neutralized myotoxic, phospholipase A and lethal activities of myotoxin, whereas edema-forming activity of myotoxin was not neutralized by these antisera. Anti-myotoxin rabbit serum neutralized most of the myotoxic activity of B. asper venom, but did not neutralize phospholipase A activity of this venom. Neutralization curves showed that myotoxicity induced by myotoxin persisted at antivenom/toxin or antiserum/toxin ratios at which phospholipase A activity was completely neutralized. This suggests that myotoxicity does not depend upon enzymatic activity of the toxin. Antiserum to myotoxin neutralized approximately 70% of myonecrosis induced by crude B. asper venom. This demonstrates that myotoxin is the main factor responsible for the development of myonecrosis in envenomations by B. asper. |
| দেশ: | Kérwá |
| প্রতিষ্ঠান: | Universidad de Costa Rica |
| Repositorio: | Kérwá |
| OAI Identifier: | oai:kerwa.ucr.ac.cr:10669/29148 |
| অনলাইন ব্যবহার করুন: | http://www.sciencedirect.com/science/article/pii/004101018790078X https://hdl.handle.net/10669/29148 |
| মুখ্য শব্দ: | Animals Antivenins Crotalid Venoms Muscles Necrosis Neutralization Tests Phospholipases A Snake venom |