Natural product based inhibitors of the thioredoxin-thioredoxin reductase system

 

שמור ב:
מידע ביבליוגרפי
Autores: Wipf, Peter, Lynch, Stephen M., Birmingham, Anne, Tamayo Castillo, Giselle, Jiménez Ardón, Allan Miguel, Campos, Nefertiti, Powis, Garth
פורמט: artículo original
Fecha de Publicación:2004
תיאור:Spiroketal naphthodecalins are readily assembled by Barton's base mediated Ullmann binaphthyl ether coupling, Dakin reactions and hypervalent iodine spirocyclization. The core structures can be further diversified by enone addition and Stille coupling reactions. Nanomolar inhibitors for the Trx/TrxR redox control system were prepared by this approach and compared to series of natural product isolates. Cytotoxicity in MCF-7 cell assays ranged from an IC50 of 1.6 to >100 microM.
País:Kérwá
מוסד:Universidad de Costa Rica
Repositorio:Kérwá
שפה:Inglés
OAI Identifier:oai:kerwa.ucr.ac.cr:10669/87509
גישה מקוונת:https://www.ncbi.nlm.nih.gov/nlmcatalog?term="Org+Biomol+Chem"%5BTitle+Abbreviation%5D
https://hdl.handle.net/10669/87509
מילת מפתח:Thioredoxin
Natural products
Inhibitors

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