Natural product based inhibitors of the thioredoxin-thioredoxin reductase system
সংরক্ষণ করুন:
| লেখক: | , , , , , , |
|---|---|
| বিন্যাস: | artículo original |
| প্রকাশনার তারিখ: | 2004 |
| বিবরন: | Spiroketal naphthodecalins are readily assembled by Barton's base mediated Ullmann binaphthyl ether coupling, Dakin reactions and hypervalent iodine spirocyclization. The core structures can be further diversified by enone addition and Stille coupling reactions. Nanomolar inhibitors for the Trx/TrxR redox control system were prepared by this approach and compared to series of natural product isolates. Cytotoxicity in MCF-7 cell assays ranged from an IC50 of 1.6 to >100 microM. |
| দেশ: | Kérwá |
| প্রতিষ্ঠান: | Universidad de Costa Rica |
| Repositorio: | Kérwá |
| ভাষা: | Inglés |
| OAI Identifier: | oai:kerwa.ucr.ac.cr:10669/87509 |
| অনলাইন ব্যবহার করুন: | https://www.ncbi.nlm.nih.gov/nlmcatalog?term="Org+Biomol+Chem"%5BTitle+Abbreviation%5D https://hdl.handle.net/10669/87509 |
| মুখ্য শব্দ: | Thioredoxin Natural products Inhibitors |