Natural product based inhibitors of the thioredoxin-thioredoxin reductase system

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書誌詳細
著者:	Wipf, Peter, Lynch, Stephen M., Birmingham, Anne, Tamayo Castillo, Giselle, Jiménez Ardón, Allan Miguel, Campos, Nefertiti, Powis, Garth
フォーマット:	artículo original
出版日付:	2004
その他の書誌記述:	Spiroketal naphthodecalins are readily assembled by Barton's base mediated Ullmann binaphthyl ether coupling, Dakin reactions and hypervalent iodine spirocyclization. The core structures can be further diversified by enone addition and Stille coupling reactions. Nanomolar inhibitors for the Trx/TrxR redox control system were prepared by this approach and compared to series of natural product isolates. Cytotoxicity in MCF-7 cell assays ranged from an IC50 of 1.6 to >100 microM.
国:	Kérwá
機関:	Universidad de Costa Rica
Repositorio:	Kérwá
言語:	Inglés
OAI Identifier:	oai:kerwa.ucr.ac.cr:10669/87509
オンライン･アクセス:	https://www.ncbi.nlm.nih.gov/nlmcatalog?term="Org+Biomol+Chem"%5BTitle+Abbreviation%5D https://hdl.handle.net/10669/87509
キーワード:	Thioredoxin Natural products Inhibitors