Natural product based inhibitors of the thioredoxin-thioredoxin reductase system
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| Nhiều tác giả: | , , , , , , |
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| Định dạng: | artículo original |
| Ngày xuất bản: | 2004 |
| Miêu tả: | Spiroketal naphthodecalins are readily assembled by Barton's base mediated Ullmann binaphthyl ether coupling, Dakin reactions and hypervalent iodine spirocyclization. The core structures can be further diversified by enone addition and Stille coupling reactions. Nanomolar inhibitors for the Trx/TrxR redox control system were prepared by this approach and compared to series of natural product isolates. Cytotoxicity in MCF-7 cell assays ranged from an IC50 of 1.6 to >100 microM. |
| Quốc gia: | Kérwá |
| Tổ chức giáo dục: | Universidad de Costa Rica |
| Repositorio: | Kérwá |
| Ngôn ngữ: | Inglés |
| OAI Identifier: | oai:kerwa.ucr.ac.cr:10669/87509 |
| Truy cập trực tuyến: | https://www.ncbi.nlm.nih.gov/nlmcatalog?term="Org+Biomol+Chem"%5BTitle+Abbreviation%5D https://hdl.handle.net/10669/87509 |
| Từ khóa: | Thioredoxin Natural products Inhibitors |