Natural product based inhibitors of the thioredoxin-thioredoxin reductase system

 

محفوظ في:
التفاصيل البيبلوغرافية
المؤلفون: Wipf, Peter, Lynch, Stephen M., Birmingham, Anne, Tamayo Castillo, Giselle, Jiménez Ardón, Allan Miguel, Campos, Nefertiti, Powis, Garth
التنسيق: artículo original
تاريخ النشر:2004
الوصف:Spiroketal naphthodecalins are readily assembled by Barton's base mediated Ullmann binaphthyl ether coupling, Dakin reactions and hypervalent iodine spirocyclization. The core structures can be further diversified by enone addition and Stille coupling reactions. Nanomolar inhibitors for the Trx/TrxR redox control system were prepared by this approach and compared to series of natural product isolates. Cytotoxicity in MCF-7 cell assays ranged from an IC50 of 1.6 to >100 microM.
البلد:Kérwá
المؤسسة:Universidad de Costa Rica
Repositorio:Kérwá
اللغة:Inglés
OAI Identifier:oai:kerwa.ucr.ac.cr:10669/87509
الوصول للمادة أونلاين:https://www.ncbi.nlm.nih.gov/nlmcatalog?term="Org+Biomol+Chem"%5BTitle+Abbreviation%5D
https://hdl.handle.net/10669/87509
كلمة مفتاحية:Thioredoxin
Natural products
Inhibitors

مواد مشابهة