Natural product based inhibitors of the thioredoxin-thioredoxin reductase system

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Autores:	Wipf, Peter, Lynch, Stephen M., Birmingham, Anne, Tamayo Castillo, Giselle, Jiménez Ardón, Allan Miguel, Campos, Nefertiti, Powis, Garth
格式:	artículo original
Fecha de Publicación:	2004
实物特征:	Spiroketal naphthodecalins are readily assembled by Barton's base mediated Ullmann binaphthyl ether coupling, Dakin reactions and hypervalent iodine spirocyclization. The core structures can be further diversified by enone addition and Stille coupling reactions. Nanomolar inhibitors for the Trx/TrxR redox control system were prepared by this approach and compared to series of natural product isolates. Cytotoxicity in MCF-7 cell assays ranged from an IC50 of 1.6 to >100 microM.
País:	Kérwá
机构:	Universidad de Costa Rica
Repositorio:	Kérwá
语言:	Inglés
OAI Identifier:	oai:kerwa.ucr.ac.cr:10669/87509
在线阅读:	https://www.ncbi.nlm.nih.gov/nlmcatalog?term="Org+Biomol+Chem"%5BTitle+Abbreviation%5D https://hdl.handle.net/10669/87509
Palabra clave:	Thioredoxin Natural products Inhibitors