Persistence of Brucella abortus in the bone marrow of infected mice

 

Guardado en:
Detalles Bibliográficos
Autores: Gutiérrez-Jiménez, Cristina, HYSENAJ, LISIENA, Alfaro-Alarcón, Alejandro, Mora-Cartín, Ricardo, Gorvel, Jean-Pierre, Arce-Gorvel, Vilma, Moreno, Edgardo, BARQUERO-CALVO, ELIAS
Formato: artículo
Fecha de Publicación:2018
Descripción:Brucellosis is a zoonotic bacterial infection that may persist for long periods causing relapses in antibiotic-treated patients. The ability of Brucella to develop chronic infections is linked to their capacity to invade and replicate within the mononuclear phagocyte system, including the bone marrow (BM). Persistence of Brucella in the BM has been associated with hematological complications such as neutropenia, thrombocytopenia, anemia, and pancytopenia in human patients. In the mouse model, we observed that the number of Brucella abortus in the BM remained constant for up to 168 days of postinfection. This persistence was associated with histopathological changes, accompanied by augmented numbers of BM myeloid GMP progenitors, PMNs, and CD4+ lymphocytes during the acute phase (eight days) of the infection in the BM. Monocytes, PMNs, and GMP cells were identified as the cells harboring Brucella in the BM. We propose that the BM is an essential niche for the bacterium to establish long-lasting infections and that infected PMNs may serve as vehicles for dispersion of Brucella organisms, following the Trojan horse hypothesis. Monocytes are solid candidates for Brucella reservoirs in the BM.
País:Repositorio UNA
Institución:Universidad Nacional de Costa Rica
Repositorio:Repositorio UNA
Lenguaje:Inglés
OAI Identifier:oai:null:11056/17646
Acceso en línea:http://hdl.handle.net/11056/17646
Palabra clave:BRUCELLA ABORTUS
BRUCELOSIS
RATA
ZOONOSIS
ZOONOTIC
BACTERIAS